de Mathématiques de Luminy
Chaouiya Claudine, Remy Elisabeth, Thieffry Denis.
Petri Net Modelling of Biological Regulatory Networks.
The complexity of biological regulatory networks often defies the intuition of the biologist and calls for the development of proper mathematical methods to model their structures and to give insight in their dynamical properties. One qualitative approach consists in modelling regulatory networks in terms of logical equations (using either Boolean or multi-level discretisations). The Petri Net (PN) formalism offers a complementary framework to analyse the dynamical properties of large systems, either from a qualitative or a quantitative point of view.
Key words: Gene regulatory networks, Logical modelling, Petri nets